Reta GLP-3R (Retatrutide) Dosage & Reconstitution Guide

Retatrutide (GLP-1/GIP/glucagon receptor tri-agonist) — sold at Prax Peptides as Reta GLP-3R — represents one of the most advanced multi-receptor peptide compounds currently under preclinical and clinical investigation. Its mechanism of simultaneously engaging three incretin-related receptors makes dosing precision especially critical.

This guide covers reconstitution, dosage calculation, and storage for Reta GLP-3R, with direct links to our free peptide dosage calculator for exact draw volumes.

What Is Reta GLP-3R (Retatrutide)?

Retatrutide is a unimolecular triple agonist that activates receptors for GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon. It is currently one of the most potent investigational compounds for metabolic research. Prax Peptides offers Reta GLP-3R in 20mg vials with verified purity.

Reta GLP-3R Reconstitution Instructions

Reta GLP-3R is supplied as a lyophilized powder. Reconstitute as follows:

1. Allow the vial to reach room temperature before opening
2. Add 2mL of bacteriostatic water for a 20mg vial (yields 10,000mcg/mL concentration)
3. Inject BAC water slowly along the vial wall — do not aim at the powder cake
4. Swirl gently for 60 seconds until fully dissolved
5. The solution should be clear to slightly yellow — do not use if cloudy or particulate

Reta GLP-3R Dosage Calculations

With a 20mg vial reconstituted in 2mL BAC water (10,000mcg/mL):

Research Dose	Draw Volume	Syringe Units (U-100)
1mg (1,000mcg)	0.1mL	10 units
2mg (2,000mcg)	0.2mL	20 units
4mg (4,000mcg)	0.4mL	40 units
8mg (8,000mcg)	0.8mL	80 units

For non-standard dose sizes or different reconstitution volumes, use the Prax Peptides peptide calculator for instant results.

Administration Frequency

In published Phase 2 clinical research on retatrutide, dosing intervals of once weekly (QW) subcutaneous injection have been used. Due to the compound’s longer half-life compared to earlier GLP-1 compounds, less frequent dosing produces more stable plasma concentrations.

Storage Guidelines

• Unreconstituted: -20°C long-term, 2–8°C short-term (up to 3 months)
• Reconstituted: 2–8°C refrigeration, use within 28 days
• Do not freeze after reconstitution

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⚠️ Research Use Only: All compounds referenced on this site are intended strictly for laboratory research purposes. They are not approved for human use or consumption by the FDA or any regulatory authority. This content is for informational purposes only and does not constitute medical advice.