SS-31 (10MG)

SS-31 (Elamipretide) 10mg – Mitochondrial Protective Research Peptide | Prax Peptides

Manufacturer: Prax Peptides
Purity: ≥99%
Form: Lyophilized Tetrapeptide (Sterile Vial)
Molecular Formula: C₃₂H₄₉N₉O₅
Molecular Weight: ~639.8 Da
CAS Number: —
Synonyms: Elamipretide, SS-31, MTP-131, Bendavia
PubChem CID: 11764719

Overview

SS-31 (Elamipretide) is a synthetic, cell-permeable mitochondria-targeting tetrapeptide belonging to the Szeto–Schiller peptide family. It was developed to selectively bind cardiolipin, a critical phospholipid located in the inner mitochondrial membrane, where it helps stabilize and optimize electron transport chain function.

By preserving mitochondrial structure and efficiency, SS-31 has become a central molecule in mitochondrial research, with studies exploring its potential in aging, metabolic dysfunction, ischemia–reperfusion injury, and mitochondrial disease models.

Chemical Structure

• Sequence: D-Arg–Dmt–Lys–Phe–NH₂
  (Dmt = 2,6-dimethyl-L-tyrosine)

• Formula: C₃₂H₄₉N₉O₅

• Molecular Weight: ~639.8 Da

• Structure Type: Aromatic-cationic tetrapeptide with a C-terminal amide

• Net Charge: Positive, facilitating mitochondrial accumulation

Mechanism of Action

SS-31 localizes at the inner mitochondrial membrane, where it binds to cardiolipin and protects against lipid peroxidation and membrane destabilization. Through this interaction, it:

• Improves mitochondrial bioenergetics and restores ATP production

• Stabilizes cristae morphology and prevents mitochondrial swelling

• Reduces reactive oxygen species (ROS) and oxidative stress

• Prevents mitochondrial permeability transition, preserving cellular integrity

These properties make SS-31 a leading research peptide in studies targeting mitochondrial dysfunction and age-related cellular decline.

Key Research Applications

1. Mitochondrial Bioenergetics & ATP Restoration

Enhances efficiency of the electron transport chain, improving energy production and P/O coupling in aging or stressed cells.

2. Cardiolipin Binding & Membrane Stabilization

Binds cardiolipin directly, preventing oxidation and maintaining mitochondrial structural integrity under stress.

3. Oxidative Stress Reduction

Shown to significantly lower ROS generation, reducing oxidative damage and promoting cell survival in preclinical models.

4. Organ Protection Research

Demonstrated cardiac, renal, neural, and retinal protective effects in animal studies particularly in ischemia-reperfusion and mitochondrial disease models.

5. Clinical and Translational Research

Advanced to human clinical trials for mitochondrial myopathies, Barth syndrome, and retinal degenerative diseases (e.g., dry AMD). Early clinical data show positive safety and efficacy trends.

Product Specifications

• Compound: SS-31 (Elamipretide)

• Concentration: 10mg per vial

• Formulation: Lyophilized sterile peptide

• Purity: ≥99% verified by HPLC and MS

• Storage:

  • Store lyophilized powder at ≤ -20°C, protected from light and moisture.

  • Once reconstituted with bacteriostatic water, divide into aliquots and refrigerate. Avoid multiple freeze-thaw cycles.

Why Researchers Choose Prax Peptides

All Prax Peptides products are manufactured in FDA-registered, cGMP-compliant U.S. laboratories. Each peptide undergoes HPLC and Mass Spectrometry verification to confirm ≥99% purity, ensuring reproducible, high-quality materials for advanced biochemical and pre-clinical research.

Legal Disclaimer

This product is for laboratory research use only. It is not approved for human or veterinary use, medical treatment, or diagnostic purposes. Handle using proper laboratory safety protocols. Keep out of reach of children.